Preserve specimens for reproducibility

High Reproducibility of Histological Characterization by Whole Virtual Slide Quantification; An Example Using Carotid Plaque Specimens

OBJECTIVE Tissue biobanks are an important source for discovery and validation studies aiming for new proteins that are causally related with disease development. There is an increasing demand for accurate and reproducible histological characterization, especially for subsequent analysis and interpretation of data in association studies. We assessed reproducibility of one semiquantative and two...

Reproducibility of the Roche Amplicor polymerase chain reaction assay for detection of infection by Chlamydia trachomatis in endocervical specimens.

tion of traditional, iron-laden beer, and two-fifths of them had increased serum ferritin. In contrast to our studies, Wapnick et al. (7) reported that serum iron concentrations increased dramatically after oral administration of vitamin C to iron-loaded, scorbutic subjects. The explanations for this difference probably lie in the timing of the vitamin C dose in relation to the serum iron measu...

Validation and reproducibility of a microarray-based gene expression test for tumor identification in formalin-fixed, paraffin-embedded specimens.

Tumors whose primary site is challenging to diagnose represent a considerable proportion of new cancer cases. We present validation study results for a gene expression-based diagnostic test (the Pathwork Tissue of Origin Test) that aids in determining the tissue of origin using formalin-fixed, paraffin-embedded (FFPE) specimens. Microarray data files were generated for 462 metastatic, poorly di...

The Digital Signature Dilemma: To Preserve or Not to Preserve

Since the mid-1990s, dozens of States, including those of the EU, have reformed their evidence laws so as to grant digital signature technologies the same proof value as handwritten signatures, as a mechanism for proving identity of authorship, consentement to obligations, and integrity of electronic records after their transmission across time and space. Yet, several archival institutions (inc...

Why preserve the not-for-profit tradition?